abstract：:Myasthenia gravis is among the rare complications after allogeneic hematopoietic stem cell transplantation and is usually associated with chronic GVHD. Herein, we report a 2-year and 10 months of age female with Griscelli syndrome, who developed severe myasthenia gravis at post-transplant +22nd month and required resp...

journal_title：Pediatric blood & cancer

authors： Unal S,Sag E,Kuskonmaz B,Kesici S,Bayrakci B,Ayvaz DC,Tezcan I,Yalnızoglu D,Uckan D

更新日期：2014-05-01 00:00:00

abstract：:Hepatic sinusoidal obstructive syndrome (HSOS) is a frequent complication in patients undergoing haematopoietic stem cell transplant (HSCT), and more rarely, in paediatric patients receiving conventional chemotherapy for solid tumours. Its diagnosis relies on a combination of clinical signs and symptoms such as hepato...

journal_title：Pediatric blood & cancer

authors： De Leonardis F,Koronica R,Bruno SD,Santoro N

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Deaths during induction chemotherapy for pediatric acute lymphoblastic leukemia (ALL) account for one-tenth of ALL-associated mortality and half of ALL treatment-related mortality. We sought to ascertain patient- and hospital-level factors associated with induction mortality. PROCEDURE:We performed a retros...

journal_title：Pediatric blood & cancer

authors： Seif AE,Fisher BT,Li Y,Torp K,Rheam DP,Huang YS,Harris T,Shah A,Hall M,Fieldston ES,Kavcic M,Vujkovic M,Bailey LC,Kersun LS,Reilly AF,Rheingold SR,Walker DM,Aplenc R

更新日期：2014-05-01 00:00:00

abstract：:Chronic lymphocytic leukemia/lymphoma (CLL) is an extremely rare disease during childhood. We report a 16-year-old female who presented with lymphadenopathies and she was diagnosed as T cell lymphoblastic lymphoma. Her chemotherapy response was minimal and clinical findings were unusual. Therefore, her biopsy specimen...

journal_title：Pediatric blood & cancer

authors： Demir HA,Bayhan T,Üner A,Kurtulan O,Karakuş E,Emir S,Özyörük D,Ceylaner S

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Corticosteroids increase risk for decreased bone mineral density, which can be worsened by vitamin D insufficiency (VDI) or deficiency (VDD). PROCEDURE:In the Vanderbilt cancer survivorship clinic, we obtained screening total 25-hydroxy vitamin D levels (VDL) in 171 cancer survivors <23 years old who were t...

journal_title：Pediatric blood & cancer

authors： Esbenshade AJ,Sopfe J,Zhao Z,Li Z,Campbell K,Simmons JH,Friedman DL

更新日期：2014-04-01 00:00:00

abstract：:Risk-adapted, response-based therapies for pediatric Hodgkin lymphoma have resulted in 5-year survival exceeding 90%. Although high-dose chemotherapy and autologous hematopoietic stem cell transplantation (AHSCT) are considered standard for most patients with relapsed or refractory Hodgkin lymphoma, a subset of childr...

journal_title：Pediatric blood & cancer

authors： Harker-Murray PD,Drachtman RA,Hodgson DC,Chauvenet AR,Kelly KM,Cole PD

更新日期：2014-04-01 00:00:00

abstract：:The majority of children with cancer live in low- and middle-income countries (LMICs) with little or no access to cancer treatment. The purpose of the paper is to describe the current status of childhood cancer treatment in Africa, as documented in publications, dedicated websites and information collected through sur...

journal_title：Pediatric blood & cancer

authors： Kruger M,Hendricks M,Davidson A,Stefan CD,van Eyssen AL,Uys R,van Zyl A,Hesseling P

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Testicular germ cell tumors (T-GCTs) occur from infancy to adulthood, and are the most common solid tumor in adolescent and young adult males. Traditionally, pediatric T-GCTs were perceived as more indolent than adult T-GCTs. However, there are few studies comparing these groups and none that specifically ev...

journal_title：Pediatric blood & cancer

authors： Cost NG,Lubahn JD,Adibi M,Romman A,Wickiser JE,Raj GV,Sagalowsky AI,Margulis V

更新日期：2014-03-01 00:00:00

abstract：:Survivors of childhood cancer are at risk for dental late effects. This systematic review summarizes associations between treatment exposures and dental late effects among survivors of childhood cancer. We included investigations with at least 20 study participants conducted for 2 or more years after completion of chi...

journal_title：Pediatric blood & cancer

authors： Gawade PL,Hudson MM,Kaste SC,Neglia JP,Constine LS,Robison LL,Ness KK

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Incidence of venous thromboembolism (VTE) in children is reported to be increasing. We examined thrombophilia testing results in children with VTE that presented in inpatient and outpatient settings to explore patterns of thrombophilia testing. PROCEDURE: PATIENTS/METHODS:Children, ages 0-20 years with VTE...

journal_title：Pediatric blood & cancer

authors： Mahajerin A,Obasaju P,Eckert G,Vik TA,Mehta R,Heiny M

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Knowledge about their past medical history is central for childhood cancer survivors to ensure informed decisions in their health management. Knowledge about information provision and information needs in this population is still scarce. We thus aimed to assess: (1) the information survivors reported to have...

journal_title：Pediatric blood & cancer

authors： Gianinazzi ME,Essig S,Rueegg CS,von der Weid NX,Brazzola P,Kuehni CE,Michel G,Swiss Paediatric Oncology Group (SPOG).

更新日期：2014-02-01 00:00:00

abstract：:Imatinib can be safely discontinued in adults with chronic myeloid leukemia (CML) where there is a prolonged complete molecular response (CMR). No data are available in the pediatric population. Six children with CML discontinued imatinib by themselves. Only three of them were in CMR but for <2 years. A significant in...

journal_title：Pediatric blood & cancer

authors： Millot F,Claviez A,Leverger G,Corbaciglu S,Groll AH,Suttorp M

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:We sought to better define the role of hematopoietic cell transplantation (HCT) in first remission (CR1) for high-risk pediatric acute myeloid leukemia (AML). PROCEDURES:Outcomes were compared among patients aged less than 21 years with cytogenetically defined poor-risk AML treated with chemotherapy, matche...

journal_title：Pediatric blood & cancer

authors： Kelly MJ,Horan JT,Alonzo TA,Eapen M,Gerbing RB,He W,Lange BJ,Parsons SK,Woods WG

更新日期：2014-02-01 00:00:00

abstract：:Medulloblastomas (MB) are classified in four subgroups: the well defined WNT and Sonic Hedgehog (SHH) subgroups, and the less defined groups 3 and 4. They occasionally occur in the context of a cancer predisposition syndrome. While germline APC mutations predispose to WNT MB, germline mutations in SUFU, PTCH1, and TP5...

journal_title：Pediatric blood & cancer

authors： Bourdeaut F,Miquel C,Richer W,Grill J,Zerah M,Grison C,Pierron G,Amiel J,Krucker C,Radvanyi F,Brugieres L,Delattre O

更新日期：2014-02-01 00:00:00

abstract：:Bridging the survival gap for children with cancer, between those (the great majority) in low and middle income countries (LMIC) and their economically advantaged counterparts, is a challenge that has been addressed by twinning institutions in high income countries with centers in LMIC. The long-established partnershi...

journal_title：Pediatric blood & cancer

authors： Barr RD,Antillón Klussmann F,Baez F,Bonilla M,Moreno B,Navarrete M,Nieves R,Peña A,Conter V,De Alarcón P,Howard SC,Ribeiro RC,Rodriguez-Galindo C,Valsecchi MG,Biondi A,Velez G,Tognoni G,Cavalli F,Masera G

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:A majority of Fanconi anemia (FA) patients will experience bone marrow failure (BMF) and androgen therapy (most often oxymetholone) may be utilized as a treatment to improve BMF-related cytopenias. However, oxymetholone is associated with toxicities making identification of other agents of interest. In this ...

journal_title：Pediatric blood & cancer

authors： Rose SR,Kim MO,Korbee L,Wilson KA,Ris MD,Eyal O,Sherafat-Kazemzadeh R,Bollepalli S,Harris R,Jeng MR,Williams DA,Smith FO

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Sickle cell disease (SCD) is an inherited blood disorder characterized by a chronic hemolytic anemia that can contribute to fatigue and global cognitive impairment in patients. The study objective was to report on the feasibility, reliability, and validity of the PedsQL™ Multidimensional Fatigue Scale in SCD...

journal_title：Pediatric blood & cancer

authors： Panepinto JA,Torres S,Bendo CB,McCavit TL,Dinu B,Sherman-Bien S,Bemrich-Stolz C,Varni JW

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Survivors of childhood brain tumors are at increased risk for neurocognitive impairments, including deficits in abilities supported by frontal brain regions. Catechol-O-methyltransferase (COMT) metabolizes dopamine in the prefrontal cortex, with the Met allele resulting in greater dopamine availability and b...

journal_title：Pediatric blood & cancer

authors： Howarth RA,Adamson AM,Ashford JM,Merchant TE,Ogg RJ,Schulenberg SE,Ogg S,Li J,Wu S,Xiong X,Conklin HM

更新日期：2014-01-01 00:00:00

abstract：:Pediatric cancer survivors have increased risk of obesity, hypertension, dyslipidemia, and type 2 diabetes, leading to premature cardiovascular disease (CVD). Multiple tissues that are involved in glucose homeostasis and lipid metabolism are adversely affected by chemotherapy. This review highlights the relevant tissu...

journal_title：Pediatric blood & cancer

authors： Rosen GP,Nguyen HT,Shaibi GQ

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:More than 60% of children with acute myeloid leukemia (AML) become long-term survivors. Most are cured using chemotherapy without hematopoietic stem cell transplantation (HSCT). We report on pubertal development and compare self-reported parenthood among AML survivors and their siblings. PROCEDURE:We includ...

journal_title：Pediatric blood & cancer

authors： Molgaard-Hansen L,Skou AS,Juul A,Glosli H,Jahnukainen K,Jarfelt M,Jónmundsson GK,Malmros J,Nysom K,Hasle H,Nordic Society of Pediatric Hematology and Oncology.

更新日期：2013-12-01 00:00:00

abstract：:Hyperglycemia during induction chemotherapy for childhood acute lymphoblastic leukemia (ALL) has been inconsistently associated with risk of infection. We investigated the incidence of hyperglycemia during induction for childhood ALL in a retrospective cohort study of 144 patients treated on a single national protocol...

journal_title：Pediatric blood & cancer

authors： Dare JM,Moppett JP,Shield JP,Hunt LP,Stevens MC

更新日期：2013-12-01 00:00:00

abstract：:Malignant degeneration frequently arises from preexisting plexiform neurofibroma in patients with neurofibromatosis type 1 (NF1). Image guided biopsy for diagnostic purposes, such as with CT guidance, can be technically challenging in these patients, as CT cannot distinguish malignant from benign areas within the same...

journal_title：Pediatric blood & cancer

authors： Koethe Y,Widemann BC,Hajjar F,Wood BJ,Venkatesan AM

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Dexamethasone is more efficacious than prednisone in the treatment of acute lymphoblastic leukemia (ALL), but has also been associated with greater toxicity. We compared neuropsychological outcomes for patients treated on DFCI ALL Consortium Protocol 00-01, which included a randomized comparison of the two s...

journal_title：Pediatric blood & cancer

authors： Waber DP,McCabe M,Sebree M,Forbes PW,Adams H,Alyman C,Sands SA,Robaey P,Romero I,Routhier MÈ,Girard JM,Sallan SE,Silverman LB

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Thyroid dysfunction has been reported in up to 52% of patients 1.4 years after treatment with (131) I-Metaiodobenzylguanidine (MIBG) in children with neuroblastoma (NBL), despite the use of potassium-iodide (KI). Our aim was to investigate if the incidence and severity of thyroid damage increases in time. M...

journal_title：Pediatric blood & cancer

authors： Clement SC,van Eck-Smit BL,van Trotsenburg AS,Kremer LC,Tytgat GA,van Santen HM

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Alveolar soft part sarcomas (ASPS) are generally chemo- and radio-resistant mesenchymal tumours, with no standardized treatment guidelines. We describe the clinical behaviour of paediatric ASPS and compare these features to previously reported adult series. PATIENTS AND METHODS:The clinical data of 51 child...

journal_title：Pediatric blood & cancer

authors： Orbach D,Brennan B,Casanova M,Bergeron C,Mosseri V,Francotte N,Van Noesel M,Rey A,Bisogno G,Pierron G,Ferrari A

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:We examined patterns of failure in pediatric patients with thoracic sarcoma and pulmonary metastases treated with intensity-modulated radiation therapy with dose-painting (DP-IMRT). PROCEDURE:Eleven pediatric patients, five with Ewing sarcoma family tumors (ESFT) and six with rhabdomyosarcoma (RMS), with pr...

journal_title：Pediatric blood & cancer

authors： Yang JC,Wexler LH,Meyers PA,Happersett L,La Quaglia MP,Wolden SL

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Most relapses from Wilms' tumor occur within 2 years from diagnosis. This study aims to describe the incidence and outcome of patients who experienced a late recurrence (LR) more than 5 years after diagnosis across several clinical trials, and to develop evidence-based recommendations for follow-up surveilla...

journal_title：Pediatric blood & cancer

authors： Malogolowkin M,Spreafico F,Dome JS,van Tinteren H,Pritchard-Jones K,van den Heuvel-Eibrink MM,Bergeron C,de Kraker J,Graf N,COG Renal Tumors Committee and the SIOP Renal Tumor Study Group.

更新日期：2013-10-01 00:00:00

abstract：PURPOSE:We conducted a pediatric phase I study to estimate the maximum tolerated dose (MTD), dose-limiting toxicities (DLT), and pharmacokinetic properties of vorinostat, a histone deacetylase (HDAC) inhibitor, when given in combination with temozolomide in children with refractory or recurrent CNS malignancies. PATIE...

journal_title：Pediatric blood & cancer

authors： Hummel TR,Wagner L,Ahern C,Fouladi M,Reid JM,McGovern RM,Ames MM,Gilbertson RJ,Horton T,Ingle AM,Weigel B,Blaney SM

更新日期：2013-09-01 00:00:00

abstract：:X-linked lymphoproliferative syndrome (XLP) is caused by mutations in SH2D1A, and is associated with overwhelming infectious mononucleosis, aplastic anemia, hypogammaglobulinemia, and B-cell lymphomas. However, the frequency of SH2D1A mutations in males who present with B NHL is unknown. Five cases of XLP were diagnos...

journal_title：Pediatric blood & cancer

authors： Sandlund JT,Shurtleff SA,Onciu M,Horwitz E,Leung W,Howard V,Rencher R,Conley ME

更新日期：2013-09-01 00:00:00

abstract：:Data on prognostic factors in pelvic PNET are minimal. We analyzed patients with pelvic PNET treated between June 2003 and November 2011 for prognostic factors. Forty-eight (13%) of 374 patients with PNET were pelvic PNET with median age 14.5 years (range: 5-33); 31 (65%) had metastases. After median follow-up of 20.4...

journal_title：Pediatric blood & cancer

authors： Biswas B,Agarwala S,Rastogi S,Khan SA,Mohanti BK,Sharma DN,Pathy S,Bakhshi S

更新日期：2013-09-01 00:00:00

abstract：:Congenital amegakaryocytic thrombocytopenia (CAMT) is characterised by neonatal thrombocytopenia, with reduced or absent bone marrow megakaryocytes, leading eventually to pancytopenia. The mean age for progression to bone marrow failure is four years, with the earliest reported being six months. We describe a CAMT pat...

journal_title：Pediatric blood & cancer

authors： Stoddart MT,Connor P,Germeshausen M,Ballmaier M,Steward CG

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Ewing sarcoma (ES), a highly aggressive tumor of children and young adults, is characterized most commonly by an 11;22 chromosomal translocation that fuses EWSR1 located at 22q12 with FLI1, coding for a member of the ETS family of transcription factors. Although genetic changes in ES have been extensively re...

journal_title：Pediatric blood & cancer

authors： Nestheide S,Bridge JA,Barnes M,Frayer R,Sumegi J

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Anthracycline agents are used for treatment of acute myeloid leukemia (AML) but may cause late-onset cardiomyopathy. Current frontline therapy for AML in North America, as reflected in the approach of the Children's Oncology Group (COG) and other pediatric consortia, is adapted from the anthracyline-intensiv...

journal_title：Pediatric blood & cancer

authors： Orgel E,Zung L,Ji L,Finklestein J,Feusner J,Freyer DR

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Kaposi sarcoma (KS) is the most common HIV-associated malignancy in sub-Saharan Africa. The presentation and outcomes of pediatric KS are not well understood. PROCEDURE:We performed a retrospective cohort analysis of 81 HIV-infected children with KS at the Baylor Children's Clinical Centres of Excellence in...

journal_title：Pediatric blood & cancer

authors： Cox CM,El-Mallawany NK,Kabue M,Kovarik C,Schutze GE,Kazembe PN,Mehta PS

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Several sickle cell clinical trials have closed due to inability to enroll patients. To limit the early cessation of a proposed clinical trial due to low accrual rates, we sought to better understand barriers and facilitators to enrolling parents of children with sickle cell anemia (SCD) into clinical trials...

journal_title：Pediatric blood & cancer

authors： Lebensburger JD,Sidonio RF,Debaun MR,Safford MM,Howard TH,Scarinci IC

更新日期：2013-08-01 00:00:00

abstract：:The identification and referral of candidate patients for phase I trials relies heavily on pediatric oncologists who must balance their own perceptions of phase I trials with the desires of the patient and his/her family. A survey was sent to 419 physicians practicing pediatric oncology at 30 different institutions. R...

journal_title：Pediatric blood & cancer

authors： Gilliam MB,Madan-Swain A,Adams JM,Pressey JG

更新日期：2013-08-01 00:00:00

abstract：:Six patients with high-risk neuroblastoma underwent the second stem cell collection round with G-CSF (5 μg/kg/day) + plerixafor (0.24 mg/kg/day) because the amount of CD34(+) cells collected during the first collection round with G-CSF alone was insufficient. The number of CD34(+) cells collected in the second collect...

journal_title：Pediatric blood & cancer

authors： Son MH,Kang ES,Kim DH,Lee SH,Yoo KH,Sung KW,Koo HH,Kim DW,Kim JY,Cho EJ

更新日期：2013-08-01 00:00:00

abstract：:Dry eye disease is a well-known late complication of radiation therapy and is often difficult to treat. We evaluated the usefulness of cyclosporine 0.05% ophthalmic emulsion for the treatment of radiation-associated dry eye in children. Eleven children received cyclosporine 0.05% emulsion twice daily after failure of ...

journal_title：Pediatric blood & cancer

authors： Hoehn ME,Kelly SR,Wilson MW,Walton RC

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:The efficacy of combination chemotherapy with methotrexate (MTX) and asparaginase is not well known in relapsed and refractory acute leukemia after contemporary therapy. PROCEDURE:A retrospective study of pediatric patients with relapsed or refractory acute myeloid leukemia (AML) who received MTX and aspara...

journal_title：Pediatric blood & cancer

authors： Buaboonnam J,Cao X,Pauley JL,Pui CH,Ribeiro RC,Rubnitz JE,Inaba H

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Over the past decade, PET-CT has been used to assess rhabdomyosarcoma (RMS) in children. However, the role of PET-CT in staging RMS is unknown. PROCEDURE:Thirty subjects with RMS, median age 7.3 years, underwent PET-CT before therapy. PET-CTs and conventional imaging (CI) were independently reviewed by two ...

journal_title：Pediatric blood & cancer

authors： Federico SM,Spunt SL,Krasin MJ,Billup CA,Wu J,Shulkin B,Mandell G,McCarville MB

更新日期：2013-07-01 00:00:00